Publications & Patents

Publications

2025

Comparini LM, Citi V, Ortore G, Daniele G, Sardelli F, Galgani G, Bray G, Filipponi C, De Carli A, Lai M, Nardone M, Calderone V, Falasca M, Pineschi M. Synthesis and biological evaluation of N-O heterobicyclic ring systems derived from 1,2-dihydropyridines as novel TRPA1 activators: implication in GLP-1 release and neuroprotection. Eur J Med Chem. 2025 Aug 30;300:118115. 

Malhotra P, Palanisamy R, Panda A, Casari I, Tirnitz-Parker JEE, O’Gara F, Trengove R, Ragunath K, Caparros-Martin JA, Falasca M. Cannabidiol Is Associated with Improved Survival in Pancreatic Cancer and Modulation of Bile Acids and Gut Microbiota. Int J Mol Sci. 2025 Aug 10;26(16):7733.

Thapa D, Patil M, Warne LN, Carlessi R, Falasca M. Cannabidiol Enhances the Therapeutic Efficacy of Olsalazine and Cyclosporine in a Murine Model of Colitis. Int J Mol Sci. 2025 Aug 16;26(16):7913.

Falasca M. Special issue entitled lipids in cancer biology by Marco Falasca. Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Aug;1870(6):159653.

Nelen J, Naponelli V, Villalgordo-Soto JM, Falasca M, Pérez-Sánchez H. Targeting Drug Resistance in Cancer: Dimethoxycurcumin as a Functional Antioxidant Targeting ABCC3. Antioxidants (Basel). 2025 May 16;14(5):599.

Panda A, Ragunath K, Pajic M, Greening DW, Falasca M. Oncogenic proteome of pancreatic cancer extracellular vesicles: sodium/myo-inositol cotransporter as a potential marker. Signal Transduct Target Ther. 2025 May 7;10(1):148.

Malhotra P, Fyfe J, Emmanouilidi A, Casari I, Mellett NA, Huynh K, Pajic M, Greening DW, Meikle PJ, Falasca M. Oncogenic small extracellular vesicles enriched in sphingosine-1-phosphate play a crucial role in pancreatic cancer progression. Cell Signal. 2025 Mar 28:111775. 

Thapa D, Patil M, Warne LN, Carlessi R, Falasca M. Enhancing Tetrahydrocannabinol’s Therapeutic Efficacy in Inflammatory Bowel Disease: The Roles of Cannabidiol and the Cannabinoid 1 Receptor Allosteric Modulator ZCZ011. Pharmaceuticals (Basel). 2025 Jan 23;18(2):148.

Parham E, Ahmad M, Falasca M. Haematological Manifestations of SARS-CoV-2: Insights into Erythropoiesis, Hepcidin Regulation, and Cytokine Storm. Int J Mol Sci. 2025 Jan 21;26(3):874.

2024

Thapa D, Patil M, Warne LN, Carlessi R, Falasca M. Comprehensive Assessment of Cannabidiol and HU308 in Acute and Chronic Colitis Models: Efficacy, Safety, and Mechanistic Innovations. Cells. 2024 Dec 5;13(23):2013.

Patil M, Thapa D, Warne LN, Lareu RR, Dallerba E, Lian J, Massi M, Carlessi R, Falasca M. Chronic metabolic effects of novel gut-oriented small-molecule GPR119 agonists in diet-induced obese mice. Biomed Pharmacother. 2024 Nov 19;181:117675.

Falasca M, Manfredi M. Extracellular vesicles and biomarker discovery. Semin Cancer Biol. 2024 Sep 6;106-107:103-105.

Patil M, Casari I, Thapa D, Warne LN, Dallerba E, Massi M, Carlessi R, Falasca M. Preclinical pharmacokinetics, pharmacodynamics, and toxicity of novel small-molecule GPR119 agonists to treat type-2 diabetes and obesity. Biomed Pharmacother. 2024 Jul 4;177:117077.

Panda A, Falasca M, Ragunath K. Extracellular vesicles in pancreatic cancer: a new era in precision medicine. Transl Gastroenterol Hepatol. 2024 Apr 10;9:29. 

Vaiaki EM, Falasca M. Comparative Analysis of the Minimal information for studies of extracellular vesicles Guidelines: Advancements and Implications for Extracellular Vesicle Research. Semin Cancer Biol. 2024 Apr 22:S1044-579X(24)00033-6.

Perera CJ, Hosen SZ, Khan T, Fang H, Mekapogu AR, Xu Z, Falasca M, Chari ST, Wilson JS, Pirola R, Greening DW, Apte MV. Proteomic profiling of small extracellular vesicles derived from mouse pancreatic cancer and stellate cells: Role in pancreatic cancer. Proteomics. 2024 Apr 3:e2300067.

Palanisamy R, Indrajith Kahingalage N, Archibald D, Casari I, Falasca M. Synergistic Anticancer Activity of Plumbagin and Xanthohumol Combination on Pancreatic Cancer Models. Int J Mol Sci. 2024 Feb 16;25(4):2340.

Welsh JA, et. al. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles. 2024 Feb;13(2):e12404.

Patil M, Casari I, Warne LN, Falasca M. G protein-coupled receptors driven intestinal glucagon-like peptide-1 reprogramming for obesity: Hope or hype? Biomed Pharmacother. 2024 Feb 9;172:116245.

2023


Thapa D, Warne LN, Falasca M.
Pharmacohistory of Cannabis Use-A New Possibility in Future Drug Development for Gastrointestinal Diseases. Int J Mol Sci. 2023 Sep 28;24(19):14677.

Fyfe J, Dye D, Razak NBA, Metharom P, Falasca M. Immune evasion on the nanoscale: Small extracellular vesicles in pancreatic ductal adenocarcinoma immunity. Semin Cancer Biol. 2023 Sep 23;96:36-47.

Fyfe J, Casari I, Manfredi M, Falasca M. Role of lipid signalling in extracellular vesicles-mediated cell-to-cell communication. Cytokine Growth Factor Rev. 2023 Oct;73:20-26.

Malhotra P, Palanisamy R, Caparros-Martin JA, Falasca M. Cancers (Basel). Bile Acids and Microbiota Interplay in Pancreatic Cancer. 2023 Jul 11;15(14):3573.

Malhotra P, Casari I, Falasca M. Can the molecules carried by extracellular vesicles help to diagnose pancreatic cancer early? Biochim Biophys Acta Gen Subj. 2023 May 24:130387.

Abu Bakar NDB, Carlessi R, Gogoi-Tiwari J, Köhn-Gaone J, Williams V, Falasca M, Olynyk JK, Ramm GA, Tirnitz-Parker JEE. TWEAK/Fn14 Signalling Regulates the Tissue Microenvironment in Chronic Pancreatitis. Cancers (Basel). 2023 Mar 16;15(6):1807.

De Giorgis V, Barberis E, Falasca M and Manfredi M. In-Depth Proteomic Analysis of Blood Circulating Small Extracellular Vesicles. Methods in Molecular Biology, 2023 2628:279-289.

Fyfe J, Malhotra P and Falasca M. Modified lipidomic profile of cancer-associated Small Extracellular Vesicles facilitates tumorigenic behaviours and contributes to disease progression. Advances in Biological Regulation, 2023 Jan; 87:100935.

2022

Selvaggi F, Melchiorre E, Casari I, Cinalli S, Cinalli M, Aceto GA, Cotellese R, Garajova I and Falasca M. Perineural Invasion in Pancreatic Ductal Adenocarcinoma: from Molecules towards Drugs of Clinical Relevance. Cancers, 2022 Nov 24; 14(23):5793.

Barberis E, Khoso S, Sica A, Falasca M, Gennari A, Dondero F, Afantitis A, Manfredi M. Precision Medicine Approaches with Metabolomics and Artificial Intelligence. Int J Mol Sci. 2022 Sep 24;23(19):11269.


Lee YT, Tan YJ, Mok PY, Kaur G, Sreenivasan S, Falasca M, Oon CE. Sex-divergent expression of cytochrome P450 and SIRTUIN 1-7 proteins in toxicity evaluation of a benzimidazole-derived epigenetic modulator in mice.
Toxicol Appl Pharmacol. 2022 Jun 15;445:116039.

Falasca V, Falasca M. Targeting the Endocannabinoidome in Pancreatic Cancer. Biomolecules. 2022 Feb 17;12(2):320.

Casari I, Emmanouilidi A, Domenichini A, Falasca M. Extracellular vesicles derived from pancreatic cancer cells are enriched in the growth factor Midkine. Adv Biol Regul. 2022 Jan;83:100857.

Lian J, Casari I, Falasca M. Modulatory role of the endocannabinoidome in the pathophysiology of the gastrointestinal tract. Pharmacol Res. 2022 Jan;175:106025.

2021


Manfredi M, Williams E, Cho WC, Falasca M. Editorial: Recent Advances in In Vitro and In Vivo Multi-Omics Analyses of Extracellular Vesicles: Therapeutic Targets and Biomarkers.
Front Mol Biosci. 2021 Oct 27;8:784436.

Perera CJ, Falasca M, Chari ST, Greenfield JR, Xu Z, Pirola RC, Wilson JS, Apte MV. Role of Pancreatic Stellate Cell-Derived Exosomes in Pancreatic Cancer-Related Diabetes: A Novel Hypothesis. Cancers (Basel). 2021 Oct 18;13(20):5224.

Malhotra P, Palanisamy R, Falasca M. Targeting pancreatic ductal adenocarcinoma: New therapeutic options for the ongoing battle. Hepatobiliary Pancreat Dis Int. 2022 Feb;21(1):4-

2020

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2019

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2018

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2017

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2016

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2015

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2014

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2013

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2012

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2011

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2010

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2009

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2008

Book Chapters (Research)

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2007

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2005

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2004

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Conference Articles (Research)

  • Falasca, M., and T. Maffucci. 2004. “Phosphatidylinositol-3-phosphate, a new crucial player in insulin signalling, is generated via a TC10-mediated phosphoinositide 3-kinase C2alpha activation.” In 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Sep 5, 2004, Munich, GERMANY: SPRINGER.
  • Falasca, M. 2004. “INHIBITION OF THE PI 3-K/AKT PATHWAY BY INOSITOL PENTAKISPHOSPHATE RESULTS IN PROAPOPTOTIC AND ANTI-ANGIOGENIC EFFECTS IN VITRO AND IN VIVO.”: INT INST ANTICANCER RESEARCH.

2003

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2002

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2001

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Conference Articles (Research)

  • Innominato, P. F., M. A. Mariggio’, E. Piccolo, T. Maffucci, S. Iacobelli, and M. Falasca. 2001. “The mechanism involved in the regulation of PLC gamma 1 activity in cell migration.”: AMER ASSOC CANCER RESEARCH.

2000

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1998

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1997

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1996

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Conference Articles (Research)

  • Corda, D., and M. Falasca. 1996. “Glycerophosphoinositols as potential markers of ras-induced transformation and novel second messengers.”
  • Corda, D., and M. Falasca. 1996. “Glycerophosphoinositols as potential markers of ras-induced transformation and novel second messengers.” In Symposium on Lipid Metabolism and Function in Cancer – Significance of Magnetic Resonance Spectroscopy (MRS) Measurements in Relation to Biochemical Processes and Cellular Control, at the 5th International Conference of Anticancer Research, Oct 18, 1995, CORFU, GREECE: INT INST ANTICANCER RESEARCH.

1995

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1994

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1993

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  • Iacovelli, L., M. Falasca, S. Valitutti, D. D’Arcangelo, and D. Corda. 1993. “Glycerophosphoinositol 4-phosphate, a putative endogenous inhibitor of adenylylcyclase.” Journal of Biological Chemistry 268 (27): 20402-20407.

1992

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1991

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Conference Articles (Research)

1990

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PATENTS

• Novel inositol phosphate derivatives. Marco Falasca, Andrew Michael Riley, Himali Yasmin Godage, Barry Victor Lloyd Potter. WO 2011064559 A3 2011

• PCT Int. Appl. (2018), WO 2018170553 A1 20180927; M. Massi, P. V. Simpson, M. Falasca: “Complexes and uses thereof”, describing the use of organometallic rhenium complexes as anticancer agents.

• PCT/AU2018/050941; P. Simpson, M. Massi, M. Falasca: “Synthetic derivatives of oleoyllysophosphatidylinositol (oleoyl-LPI) and uses thereof”, describing the use of synthetic analogues of oleyl-LPIas agonist for the GPR119 receptor.